Imaging Atherosclerotic Plaque Inflammation via Folate Receptor Targeting Using a Novel 18 F-Folate Radiotracer
نویسندگان
چکیده
منابع مشابه
Folate receptor-β imaging using 99mTc-folate to explore distribution of polarized macrophage populations in human atherosclerotic plaque.
UNLABELLED In atherosclerotic plaques, the risk of rupture is increased at sites of macrophage accumulation. Activated macrophages express folate receptor-β (FR-β), which can be targeted by folate coupled to radioactive ligands to visualize vulnerability. The aim of this study was to explore the presence of activated macrophages in human atherosclerotic plaques by (99m)Tc-folate imaging and to ...
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The key function of the heart, a well-orchestrated series of contractions, is controlled by cardiac action potentials. These action potentials are initiated and propagated by a single isoform of voltage gated sodium channels - SCN5A. However, linking changes in SCN5A expression levels to human disease in vivo has not yet been possible. Radiocaine, an F-18 radiotracer for positron emission tomog...
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1Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; 2Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; 3Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; 4Department of Surgery,...
متن کاملTargeted folate receptor β fluorescence imaging as a measure of inflammation to estimate vulnerability within human atherosclerotic carotid plaque.
UNLABELLED The probability of atherosclerotic plaque rupture and its thrombotic sequelae are thought to be increased at sites of macrophage accumulation. Folate receptor β (FR-β) is present on activated macrophages but not on quiescent macrophages or other immune cells. By conjugating the ligand folate with a fluorescent contrast agent, fluorescein isothiocyanate (FITC), we aimed to explore the...
متن کامل18 F-click labeling and preclinical evaluation of a new 18 F-folate for PET imaging
BACKGROUND The folate receptor (FR) is a well-established target for tumor imaging and therapy. To date, only a few 18 F-folate conjugates via 18 F-prosthetic group labeling for positron emission tomography (PET) imaging have been developed. To some extent, they all lack the optimal balance between efficient radiochemistry and favorable in vivo characteristics. METHODS A new clickable olate p...
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ژورنال
عنوان ژورنال: Molecular Imaging
سال: 2014
ISSN: 1536-0121,1536-0121
DOI: 10.2310/7290.2013.00074